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Artigo Científico | Biocompatibilidade | Inglês | 10/10/2006
Autores: Andrea Machado Costa, Gloria de Almeida Soares, Ingrid Russoni de Lima, Ivan Napoleão Bastos, José Mauro Granjeiro
Palavras-chave: bone graft, granules, hydroxyapatite, zinc
Resumo: Hydroxyapatite (HA) is capable of accepting substitute ions within its lattice, including zinc ions. Zinc is a trace element that activates the osteogenesis of osteoblastic cells and therefore plays an important role in the activity of alkaline phosphatase enzyme. The purpose of this work was to produce and characterize 5% mol Zn bioceramic in granular form (Zn-granules) for clinical applications and compare it with granules made from HA by using the same production route. Granules with addition of porogen agents were produced from powders of HA and zinc-containing HA by uniaxial pressing and heat treatment. The granules were subsequently ground and sieved. The results indicated that zinc contributed to the reduction of sample crystallinity and formed a biphasic structure after calcination at 1200 °C. Additionally, zinc release from granular material may have clinical applications as bone graft.
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